Team-oriented process programming

Team-oriented process programming promises to provide significant support for the planning, directing, and controlling of software engineering projects. In this paper we apply process programming to software engineering teams and show how this can provide powerful new capabilities for the management of software projects. We identify key issues which must be addressed to apply process programming to teams, and present our vision for team-oriented process programming

An analysis of Late Woodland ceramics from Peter Pond Lake, Saskatchewan

Recent archaeological surveys on Peter Pond Lake have provided an opportunity to better elucidate the Late Woodland period of occupation in the upper Churchill River basin of northwestern Saskatchewan. Previous studies identified two pottery-bearing cultures in the region. This included the Kisis complex of the well-documented Selkirk composite, which is characterized by Winnipeg Fabric-impressed ware and dates from approximately A.D. 1300 through to the historic period. The second was a lesser-known archaeological entity represented by limited pottery recoveries from just two sites in the region. Early interpretations proposed this latter “Narrows” pottery represented an incursion of the plains adapted Old Women’s phase into the region, with a suggested age of approximately A.D. 1000 to 1300. Through a comprehensive analysis of pottery assemblages recently recovered from over twenty sites in the Peter Pond Lake region, this study was able to further validate the original description of the Kisis complex, but more significantly, propose a new pottery ware and complex for the enigmatic Narrows pottery assemblages. As a result, this pottery is now formally classified as Narrows Fabric-impressed ware and is considered characteristic of the Buffalo Lake complex. This complex is centered on Peter Pond Lake and appears to have an extensive presence in the region. Recently obtained radiocarbon dates indicate it is slightly younger than originally believed, and spanned from approximately A.D 1200 to 1500. Unlike previous interpretations, which suggest this pottery represents a plains influence in the region, the Buffalo Lake complex is considered a boreal forest manifestation, with origins that lie in the woodlands to the southeast. The pottery shares particular affinities with contemporaneous Sandy Lake ware that has a distribution extending from east-central Saskatchewan through to northwestern Ontario and Minnesota, with additional influences evident from Winnipeg Fabric-impressed ware found throughout northern Saskatchewan, Manitoba and Ontario

An analysis of Late Woodland ceramics from Peter Pond Lake, Saskatchewan

Recent archaeological surveys on Peter Pond Lake have provided an opportunity to better elucidate the Late Woodland period of occupation in the upper Churchill River basin of northwestern Saskatchewan. Previous studies identified two pottery-bearing cultures in the region. This included the Kisis complex of the well-documented Selkirk composite, which is characterized by Winnipeg Fabric-impressed ware and dates from approximately A.D. 1300 through to the historic period. The second was a lesser-known archaeological entity represented by limited pottery recoveries from just two sites in the region. Early interpretations proposed this latter "Narrows" pottery represented an incursion of the plains adapted Old Women's phase into the region, with a suggested age of approximately A.D. 1000 to 1300. Through a comprehensive analysis of pottery assemblages recently recovered from over twenty sites in the Peter Pond Lake region, this study was able to further validate the original description of the Kisis complex, but more significantly, propose a new pottery ware and complex for the enigmatic Narrows pottery assemblages. As a result, this pottery is now formally classified as Narrows Fabric-impressed ware and is considered characteristic of the Buffalo Lake complex. This complex is centered on Peter Pond Lake and appears to have an extensive presence in the region. Recently obtained radiocarbon dates indicate it is slightly younger than originally believed, and spanned from approximately A.D 1200 to 1500. Unlike previous interpretations, which suggest this pottery represents a plains influence in the region, the Buffalo Lake complex is considered a boreal forest manifestation, with origins that lie in the woodlands to the southeast. The pottery shares particular affinities with contemporaneous Sandy Lake ware that has a distribution extending from east-central Saskatchewan through to northwestern Ontario and Minnesota, with additional influences evident from Winnipeg Fabric-impressed ware found throughout northern Saskatchewan, Manitoba and Ontario

Late-Time Convection in the Collapse of a 23 Solar Mass Star

The results of a 3-dimensional SNSPH simulation of the core collapse of a 23 solar mass star are presented. This simulation did not launch an explosion until over 600ms after collapse, allowing an ideal opportunity to study the evolution and structure of the convection below the accretion shock to late times. This late-time convection allows us to study several of the recent claims in the literature about the role of convection: is it dominated by an l=1 mode driven by vortical-acoustic (or other) instability, does it produce strong neutron star kicks, and, finally, is it the key to a new explosion mechanism? The convective region buffets the neutron star, imparting a 150-200 km/s kick. Because the l=1 mode does not dominate the convection, the neutron star does not achieve large (>450 km/s) velocities. Finally, the neutron star in this simulation moves, but does not develop strong oscillations, the energy source for a recently proposed supernova engine. We discuss the implications these results have on supernovae, hypernovae (and gamma-ray bursts), and stellar-massed black holes.Comment: 31 pages (including 13 figures), submitted to Ap

ERBE and AVHRR Cirrus cloud fire study

Understanding the impact of cirrus clouds on the global radiation budget is essential to determining the role of clouds in the process of climate change. The ongoing Earth Radiation Budget Experiment (ERBE) is charged with measuring the global radiation balance at the top of the atmosphere. The International Satellite Cloud Climatology Project (ISCCP) is measuring global cloud amounts and properties over a time frame similar to ERBE. Specific cloud properties are absent from the ERBE program, while ISCCP lacks the broadband radiances necessary to determine the total radiation fields. Together, results from these two global programs have the potential for improving the knowledge of the relationship between cirrus clouds and the Earth radiation balance. The First ISCCP Regional Experiment (FIRE), especially its cirrus Intensive Field Observations (IFO), provides opportunities for studying radiation measurements from the ERBE taken over areas with known cirrus cloud properties. Satellite measurements taken during the IFO are used to determine the broadband radiation fields over cirrus clouds and to examine the relationship between narrowband and broadband radiances over various known scenes. The latter constitutes the link between the ERBE and the ISCCP

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia.

Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of filopodia and lamellipodia. Consistent with this finding, the particles are enriched in proteins found in focal adhesions, which attach macrophages to the substrate. The release of particles is abolished by blocking cell movement (either by depolymerizing actin with latrunculin A or by inhibiting myosin II with blebbistatin). Confocal microscopy and NanoSIMS imaging studies revealed that the plasma membrane-derived particles are enriched in 'accessible cholesterol' (a mobile pool of cholesterol detectable with the modified cytolysin ALO-D4) but not in sphingolipid-sequestered cholesterol [a pool detectable with ostreolysin A (OlyA)]. The discovery that macrophages release cholesterol-rich particles during cellular locomotion is likely relevant to cholesterol efflux and could contribute to extracellular cholesterol deposition in atherosclerotic plaques

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces new proteasome synthesis promoted by the transcription factor RPN4. This ensures that proteasome activity is matched to demand. This transcriptional feedback loop is conserved in mammals, but its molecular basis is not understood. Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap “n” collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts (MEFs). Promoter-reporter assays revealed the importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes. Nrf1^(−/−) MEFs were impaired in the recovery of proteasome activity after transient treatment with the covalent proteasome inhibitor YU101, and knockdown of Nrf1 in human cancer cells enhanced cell killing by YU101. Taken together, our results suggest that Nrf1-mediated proteasome homeostasis could be an attractive target for therapeutic intervention in cancer